We are pleased to invite you to attend the dissertation thesis defence of Tomáš Kudera

The chronic bacterial dysbiosis has become a known risk resulting from inappropriate antimicrobial therapy of infectious diarrhoea. Moreover, association between such microbial disturbances and onset of gastrointestinal carcinogenesis has been increasingly discussed. Plant-derived constituents such as compounds and extracts of medicinal plants have a high therapeutic potential for their multiple biological activities. In this thesis, in vitro selective inhibitory effects were determined against several diarrheagenic bacteria and intestinal cancer cells in cases of extracts from six Cambodian and Philippine antidiarrheal plants and phytochemical analogues of four quinoline alkaloids. Quantitative structure-property relationship literature analysis of (iso)quinolines identified compounds with therapeutic potential, and investigation of their chemotaxonomic distribution in relation to ethnobotanical profile unveiled some pharmacologically important plant taxa. This study identifies plants and plant-derived products that are worth further research focused on development of a new efficient and safer antibacterial/anticancer drugs employed in the treatment of diarrhoea and associated intestinal cancers.

Date of the PhD defence

26.3.2024 (10:30 AM)

Title of the PhD Thesis

Effect of plant-derived extracts and compounds on human intestinal bacteria and cells in vitro


Department of Crop Sciences and Agroforestry

Study Program

Tropical Agrobiology and Bioresource

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